Structural elucidation of substrate-bound aminoglycoside acetyltransferase (3)-IIIa.
Canonical aminoglycosides are a large group of antibiotics, where the part of chemical diversity stems from the substitution of the neamine ring system on positions 5 and 6.Certain aminoglycoside modifying enzymes can modify a broad range of 4,5- and 4,6-disubstituted aminoglycosides, with some as many as 15.This study presents the structural and k